TRPC3 and cardiac hypertrophy: Studies have consistently shown that particularly DAG-activated TRPC3 and TRPC6 (TRPC3/6) channels function as an important mediator of GPCR-stimulated Ca2+ signaling pathway that may participate in pathological cardiac hypertrophy (Kuwahara et al., 2006; Nakayama et al., 2006; Onohara et al., 2006).