The initiation of hypertrophic stimuli for myocardial hypertrophy has been described through mechanical stress and neurohumoral mechanism that are associated with the release of factors such as angiotensin II (Ang II), endothelin-1 (ET-1) and norepinephrine(Dorn and Force, 2005; Heineke and Molkentin, 2006). Here, EDN1 is linked to cardiac hypertrophy.