B-CLL cells have a greater than twofold increase in expression of a subset of GPCRs that are highly expressed (ΔCt ∼18 or less) in normal B cells (Figure 1C): GABBR1 (GABA B1 receptor, ΔCt = 16), CNR2 (CB2 cannabinoid receptor, ΔCt = 17), CELSR1 (an orphan adhesion receptor, ΔCt = 17), and GPR92 (aka LPAR5, a lysophosphatidic acid receptor, ΔCt = 18). This evidence concerns the gene CELSR1 and B-cell chronic lymphocytic leukemia.