Moreover, simvastatin could reverse 6-OHDA-induced reduction of SOD activity in the midbrain of PD mice (densitometry of 6-OHDA group: 5.47 ± 0.79; densitometry of simvastatin plus 6-OHDA group: 7.65 ± 0.93; Figure 9D). Here, SOD1 is linked to Parkinson disease.