MTOR and neoplasm: A number of kinases, proto-oncogenes, and tumor-suppressor genes, including PI3K, PDK1, phosphatase and tensin homolog, Akt, TCL1, tuberous sclerosis complex 1/2 (TSC1/2), FOXO, mechanistic target of rapamycin (mTOR), or eukaryotic translation initiation factor 4E, are contained in this network [2, 3, 5].