FCGR2A and dengue disease: Severe dengue disease is widely held to be the result of increased virus load arising from a phenomenon known as antibody-dependent enhancement (ADE), wherein antibodies to a particular DENV serotype, which can confer lifetime homotypic immunity to that serotype, bind and promote the uptake of a heterotypic DENV into Fcγ receptor (FcγR)-bearing cells and augment the severity of dengue illness7.