In an adjusted proportional hazards model including WHO performance status and levels of ALP, CEA and CRP, an elevated level of serum CA 19-9 was associated with a significant relative reduction in survival (adjusted HR = 4.35 (95% CI 2.89–8.28) in patients with tumours harbouring BRAF mutation (Table 2). The gene discussed is BRAF; the disease is neoplasm.