AGRN and lip and oral cavity carcinoma: Agrin is a multi-domain protein expressed as either a membrane protein or secreted in the ECM.9 Agrin has been shown to act as a sensor in developing oncogenic signals associated with the ECM in hepatic carcinomas.9 In the context of OSCC progression, a previous study of our group showed that agrin has high expression in OSCC and has a role on cell migration, adhesion and resistance to chemotherapy,10 suggesting that agrin also has an oncogenic role in oral cancer.