The extracellular matrix (ECM) modulates the hallmarks of cancer, and changes in its dynamics contribute to tumour progression.7 Some components of the ECM, which include heparan sulphate proteoglycans, are frequently overproduced in cancer.8 Agrin is one of the main heparan sulphate proteoglycans present in the ECM. The gene discussed is GPC3; the disease is neoplasm.