In addition to influencing agrin expression, EGR-1 is involved, either directly or indirectly, in the process of agrin cleavage.61 Agrin is known to activate FAK and it is a critical regulator of YAP/TAZ function.62 A recent work indicates that YAP/TAZ are major oncogenes associated with OSCC.63 Since EGR-1 is a factor that also regulates the transcription of YAP and TAZ (according to PAZAR database), it may be interesting to explore whether EGR-1 silencing affects tumour progression or if agrin depletion affects YAP/TAZ activity in oral cancer cells. The gene discussed is AGRN; the disease is neoplasm.