In addition, agrin can help distinguish between primary lesions of liver and metastasis with a high sensitivity and specificity.51 Oral cancer is a multi-stage disease, generated by sequentially malignant events, from epithelial precursor lesions to invasive carcinoma.2 Considering the higher expression of agrin in dysplastic and malignant keratinocytes, and its secretion mainly by cancer cells, it could play a role and/or reflect the process of malignant progression. Here, AGRN is linked to cancer.