We first tested its role in a well-established cell culture model of inflammation that recapitulates some features of psoriasis by stimulating HaCaT cells with a cocktail of cytokines M5 (including TNF-α, IL-17A, IL-22, IL-1α, and Oncostatin-M, 10 ng/ml)20,21. The gene discussed is IL22; the disease is psoriasis.