GPR15LG and psoriasis: To determine whether C10orf99 participates in the pathogenesis of psoriasis by promoting keratinocyte proliferation, we locally knocked down C10orf99 expression in mouse back skin by injecting lentiviral particles carrying the C10orf99 shRNA and examined the impact of C10orf99 depletion on the development of IMQ-induced psoriasis24,25.