TNF and infection: In contrast, a dose of 10 mg/L INH/RIF provided a partial protection, with a survival delayed by one week, reduced body weight loss and bacterial burden on day 32, while 100 mg/L INH/RIF on day 14 to 35 allowed TNFα−/− mice to survive up to 78 days post-infection with controlled bacterial burden (Fig. 5A,B).