Median age at operation and tumour size for the group of tumours with APC/CTNNB1/ZNRF3 alterations were 52.5 years and 10 cm respectively and were not significantly different from those without mutations (46 yrs, p = 0.3517, and 10 cm, p = 0.5731; Supplementary Fig. S13a,b). This evidence concerns the gene APC and neoplasm.