ZNRF3 and neoplasm: We have screened 61 tumours originating from 52 patients for mutations in members of Wnt/β-catenin signaling pathway; APC, AXIN2, CTNNB1, and ZNRF3. Mutations in APC, CTNNB1, and ZNRF3 genes were found in two, six and one sample respectively whereas none of the analyzed samples harboured any mutations in AXIN2. One of the APC mutations was germline, c.4666_4667insA (p.T1556NfsTer3), and the other was a somatic mutation, c.4391_4394del (p.E1464GfsTer8) (Supplementary Fig. S1).