TNFRSF11B and Plasmodium falciparum malaria: An association between CFHb and angiopoietin-2 has been previously demonstrated in adults12 and children13 with falciparum malaria; however, we now extend these findings by demonstrating an association in P. knowlesi between CFHb and both angiopoietin-2 and OPG that is independent of parasite biomass.