EGFR and cancer: Because EGFR and ErbB2 (a.k.a human EGFR2, HER2) are often overexpressed in gastrointestinal cancers and agents targeting these receptors have been used in cancer therapy3, 27, 39, we examined the effect of an EGFR inhibitor, PD153035, and an ErbB2 inhibitor, CP-724714, on ERK activity dynamics.