As abnormal expression of AQP-1 and ZO-1 leads to degenerated function of the peritoneum, and abnormal expression of PPAR-γ is related to peritoneal fibrosis and neoangiogenesis, we determined the effect of rosiglitazone on the expression of AQP–1, ZO-1, and PPAR-γ. The gene discussed is AQP1; the disease is Peritoneal Fibrosis.