To determine whether DDX41 and cGAS functioned in vivo to suppress infection, we subcutaneously inoculated the CD11cCre-DDX41 and cGas KO mice with MLV and measured infection levels in the draining lymph node; wild-type (Ddx41f/f mice without Cre) and Stinggt/gt mice served as controls. The gene discussed is CGAS; the disease is infection.