More than half of these have been previously implicated with effects of developmental ethanol exposure in cell culture models (ERBB2, RAC1, ROBO1, SLIT1 (Tyler and Allan 2014); CDC42, CTNNB1, HSP90AB1, ROBO1 (Garic et al. 2014));, in chicken embryos (CTNNB1, CDC42, GSK3B, HSP90AB1, MYH10 (Berres et al. 2017)); in human embryonic cells (RHOB (Mandal et al., 2015)); in a GWA study for alcohol dependence in people (CTNNB1, SLIT1 (Edenberg et al. 2010)); and in gene expression microarray analysis of human frontal cortex (HSP90AB1 (Lewohl et al. 2000); CUL1 (Liu et al. 2016)). The gene discussed is RAC1; the disease is alcohol dependence.