Despite the potency of this double‐negative feedback loop leading to mutually exclusive expression of miR‐200 and ZEB1 (Gregory et al, 2008; Brabletz & Brabletz, 2010), miR‐200 targets many other transcripts with potential relevance to cancer progression (Bracken et al, 2014, 2016; Perdigao‐Henriques et al, 2016). The gene discussed is ZEB1; the disease is cancer.