SACK1H and colorectal cancer: Studies on HCT116 colorectal cancer cells and ameloblast cells also showed that the interaction between FAM83H and CK1α was essential for correct organisation of the keratin cytoskeleton, as a mutant of FAM83H unable to interact with CK1α and chemical inhibition of CK1α hindered the proper organisation of the keratin cytoskeleton [49,52].