We show in our study that hES-AS protect in-vitro spinal cord MNs from oxidative stress produced by H2O2. In ALS patients, a decrease of the astroglial GLT-1 glutamate transporter is observed [16], leading to decreased glutamate uptake in the synaptic clefts of the spinal cord. This evidence concerns the gene SLC1A2 and amyotrophic lateral sclerosis.