The top-10 pathways, which, if inhibited, have resulted in a better efficiency reduction of the network are: ‘LXR/RXR Activation’, ‘Extrinsic Prothrombin Activation Pathway’, ‘Estrogen Receptor Signaling’, ‘Human Embryonic Stem Cell Pluripotency’, ‘Ethanol Degradation IV’, ‘RAR Activation’, ‘Fatty Acid oxidation’, ‘Bladder Cancer Signaling’, ‘Factors Promoting Cardiogenesis in Vertebrates’ and ‘Glioma Invasiveness Signaling’. The gene discussed is ESR1; the disease is glioma.