ESR1 and breast cancer: Additionally, in a subanalysis of ER positive cases (n = 1983) versus controls (n = 4687) and PR positive cases (n = 1580) versus controls (n = 4687) the same 17q25.3 locus top hit (rs9913477) emerged, but was statistically significantly associated with BC after FDR correction only for the largest subgroup of ER positive cases (INFO r2 = 0.99, MAF = 0.58; OR = 1.53, 95% CI = 1.30–1.81; p = 4.29 × 10–7; FDR = 0.027).