A second AMBER gene-based analysis of 184 genes in the insulin/insulin-like growth factor, leptin, and growth hormone pathways identified BAIP2 and CALM2, and AIAP2 and CSNK2A1 as the most significant gene associations (gene-based p ≤ 0.01) with both overall and ER positive BC, respectively [58]. Here, ESR1 is linked to breast cancer.