While Pc silencing is not globally altered in a scrib1 mutant background, the transcriptional changes that correlated with altered Pc-binding at specific loci allowed us to identify three novel Pc target genes (Atf3, Ets21C, Ilp8), which are implicated in tissues stress responses and tumour growth in many proliferating tissues [36–38, 43, 44]. The gene discussed is ATF3; the disease is neoplasm.