Consequently, we found that modulation of DNA methylation on the distal DRE, cg03190578, by dcas9-DNMT3A-3 L significantly decreased cancer cell migration suggesting an oncogenic function for HDAC11 in liver cancer, which was confirmed by increased cell migration upon overexpression of HDAC11 (Fig. 4b). The gene discussed is DNMT3A; the disease is liver cancer.