The variations (missense SNPs/splice junction variations) on ABCA10 (rs496849), BHLHE41 (rs11048413), CD200 (rs1131199), CYBB (not reported in dbSNP), GATM (rs1288775), GBP1 (rs1048425), LEPR (rs1137101), LMO7 (2 insertions), LRP1 (splice junction), POP4 (splice junction), PTCH1 (splice junction), SCN7A (rs7565062, rs6738031, 1 insertion), SLFN12L (rs2304968), TTC5 (rs3742945), and VEPH1 (rs11918974) are located on genes previously associated to COPD (Table 1). The gene discussed is LEPR; the disease is chronic obstructive pulmonary disease.