Moreover, we detected altered transcript expression of ABCA10, ADAM19, BHLHE41, CD200, CYBB, GATM, GBP1, HJURP, KIT, LEPR, LMO7, LRP1, MCRS1, POP4, PTCH1, SCN7A, TLR8, TTC5 and VEPH1 in COPD and emphysematous lungs compared to control subjects in various datasets (GSE: 29133, 22,148, 1650, 47,460 and 54,837; Additional file 1: Table S3) [33–37]. The gene discussed is POP4; the disease is chronic obstructive pulmonary disease.