NLRC4 and psoriasis 14, pustular: Other downregulated gene transcripts related to pattern recognition in neutrophils include IFNGR1, LTB4R, TLR1, TLR5, MYD88, NLRP3 and NLRC4. The downregulation of these genes may negatively control AMP-mediated neutrophil activation, thus contributing to the resolution of inflammation in GPP patients.