Of these, S100A8, S100A9, S100A12, IL-8, MMP8 and MMP9 encode antimicrobial peptides (AMPs) or chemoattractant molecules previously known to be involved in GPP pathogenesis, and PLK1 and IRF7 were identified in the current research. The gene discussed is S100A9; the disease is psoriasis 14, pustular.