Several reproducible GWA studies confirmed these well-established susceptibility genes, and they were found to be replicated for association with T2D and diabetes-related traits in or near SLC30A8, KCNQ1, CDC123, HNF1B, KCNJ11, TCF7L2, CDKAL1, CDKN2A/2B, PPARG, HHEX, IGF2BP2, GLIS3, JAZF1, WFS1, and MTNR1B in Europeans and East Asians. The gene discussed is HHEX; the disease is type 2 diabetes mellitus.