For GBM, the driver gene candidates are highly enriched for cancer related pathways (Table 2), such as Pathway in cancer (p = 1.44e-24), Glioma (p = 5.09e-24), Melanoma (p = 1.41e-09), p53 signaling pathway (p = 8.11e-09) and mTOR signaling pathway (p = 2.29e-06). Here, TP53 is linked to central nervous system cancer.