The cumulative cancer incidence estimate for patients with viral loads between 200 and 999 copies/mL was markedly reduced after adjustment (crude risk of 10.7% vs. standardized risk of 6.82%); race/ethnicity, year of ART initiation, ART regimen, baseline CD4 count, and study site accounted for 75% of the change in estimate in this viral load category. The gene discussed is CD4; the disease is cancer.