Main additional differences include: gradient of hormone receptors, in which they are less concentrated in the proximal colon and more concentrated in the rectum [38, 39]; the mutation rates in rectal cancer are higher[40]; and the molecular mechanism of tumor development is not the same based on the location, CIN incidence is high in rectal cancer and MSI in proximal colon cancer [41, 42]. Here, NR4A1 is linked to rectal cancer.