Although there is enthusiasm for the use of immune checkpoint inhibitors for treating multiple malignancies, and several studies showed PD-1 and PD-L1 expression in murine models of medulloblastoma [24, 25], the relatively low levels of PD-1-expressing T cells, tumor expressed PD-L1, and tumor mutational burden in medulloblastomas, consistent with a prior report [26], indicate that immune checkpoint inhibitors as a monotherapy should not necessarily be prioritized for therapeutic considerations based on biomarker expression. Here, CD274 is linked to neoplasm.