Clinical data have recently implicated low IGF1 in flare-ups of inflammatory bowel disease (Krakowska-Stasiak et al. 2017), while basic studies have demonstrated that IGF1 directly inhibits pro-inflammatory cytokines in multiple animal cell types (Ji et al. 2017; Onnureddy et al. 2015), inducing LPS-induced cytokine expression (Onnureddy et al. 2015). The gene discussed is IGF1; the disease is inflammatory bowel disease.