The sequential actions of nuclear SIRT1 and RELB induce SIRT3 expression and increase mitochondrial biogenesis during sepsis adaptation.6 Thus, the cellular mechanisms that control mitochondrial OXPHOS gene expression could be exploited in therapeutic approaches against sepsis.15, 16 In this study, we investigated the protective role of SIRT3 in septic shock to facilitate therapeutic drug discovery. The gene discussed is SIRT3; the disease is Sepsis.