This significant increase in the number of GFP-PAX3FOXO1 + cells is coupled with a reduction in the ratio of TUNEL-positive cells, indicating that tp53M214K mutant zebrafish provide a susceptible environment for PAX3-FOXO1 + cellular persistence and ultimately tumor development (Figure 2—figure supplement 1E–G; Figure 2—figure supplement 2). The gene discussed is PAX3; the disease is neoplasm.