Besides, the blood biochemistry test show that treatment with Biotin-ss-CPT effectively alleviated the toxicity of free CPT such as cardiotoxicity, hepatotoxicity, and nephrotoxicity in tumor-bearing nude mice (Figure 5(B)), as reflected by the liver function indicators (ALB, albumin; AST, aspartate aminotransferase; TP, total protein; GLB, globulin), kidney function indicator (BUN, blood urea nitrogen) and myocardial enzyme indicator (LDH, lactate dehydrogenase). This evidence concerns the gene ALB and neoplasm.