Since endothelial cell-specific inhibition of NF-κB protects mice from atherosclerosis (80), and since ANRIL is a downstream target of TNFα/NF-κB signaling, targeting TNFα or NF-κB may theoretically be considered to be athero-protective via inhibiting ANRIL-YY1-mediated IL-6/8 production. The gene discussed is TNF; the disease is atherosclerosis.