These studies have also demonstrated that inducers of HO-1, such as hemin and cobalt protoporphyrin IX (CoPPIX), protected mice infected with malaria or suffering from other diseases, such as polymicrobial sepsis, from ALI/ARDS (Pamplona et al., 2007; Fei et al., 2012; Luo et al., 2014). Here, HMOX1 is linked to acute respiratory distress syndrome.