However, leptin stimulation of these HIV+ monocytes partially inhibited the production of ROS (Sánchez-Pozo et al., 2003), this could be either the desensitization of HIV+ monocytes for leptin as observed in other hyper-inflammatory states such as sepsis, in which the monocytes skewed into hypo-inflammatory/anergy state by LPS stimulation (Karp et al., 1998) and results in the attenuation of oxidative burst (Von Knethen and Brüne, 2001) or the consistency of anti-apoptotic function of leptin with the inhibition of oxidative burst in HIV+ monocytes (Najib and Sánchez-Margalet, 2002). Here, LEP is linked to Sepsis.