As shown here for the first time, the HLA-score of an HNSCC patient, which is the sum of crude ln-transformed HR of the eight HLA traits, is inversely correlated with the PFS and is a Pi. Multivariate analysis in the TC revealed significant altered PFS in carriers of homozygous Cw and DRB4, four HLA-B alleles, and two haplotypes (19). This evidence concerns the gene HLA-B and head and neck squamous cell carcinoma.