In non-small cell lung carcinoma (NSCLC) models, dual treatment with the thioredoxin reductase-1 (TXNRD1) antioxidant inhibitor auranofin and MK2206 induced cancer cell-specific apoptosis through ROS-stimulated JNK signaling (99). The gene discussed is TXNRD1; the disease is non-small cell lung carcinoma.