Additional in vitro functional studies showed overexpression of vimentin in a highly invasive subline of brain metastasis lung cancer cells overexpressing MALAT1, while overexpression of E-cadherin was observed when MALAT1 was silenced, indicating that MALAT1 overexpression promotes lung cancer brain metastasis by inducing EMT (140). This evidence concerns the gene CDH1 and lung carcinoma.