Similar to EGFR and KRAS mutations and ALK rearrangements, several other molecules such as liver kinase B1 (LKB1, also known as STK11), proto-oncogene tyrosine-protein kinase ROS1, and C-MET that encodes the hepatocyte growth factor receptor were found to be implicated in the development of lung cancer (75–79). The gene discussed is ROS1; the disease is lung carcinoma.