The capacity to identify metastatic disease based on proto-oncogenes such as Kirsten rat sarcoma viral oncogene homolog (KRAS) and tumor suppressor p53 (TP53), present in only half of the lung cancer patients (47 and 50%, respectively) (25), demands a more broaden and deepened spectrum of the investigation of primary lung cancers, the molecular interactions with other cells, and the tumor microenvironment. This evidence concerns the gene KRAS and lung cancer.