EGFR and non-small cell lung carcinoma: While C-MET amplification is one of the factors commonly associated with disease progression (88), Benedettini et al., in a first cohort of 23 NSCLC samples of patients harboring an EGFR activating mutation, showed that both C-MET phosphorylation and expression were significantly associated with shorter time to progression, correlating with de novo resistance to EGFR TKI.