In a cohort of 874 brain metastases samples, of which 295 NSCLC, Capper et al. showed that, although a total of 51/874 samples harbored a BRAF V600E mutation, only 1/295 NSCLC brain metastases (~0.3%) was BRAF mutant (84). This evidence concerns the gene BRAF and non-small cell lung carcinoma.