An anti-CD56 ADC, lorvotuzumab mertansine (IMGN901) was tested in 9 patients with hematological malignancies including AML (NCT02420873), in 2 studies in 181 patients with small cell lung cancer (NCT01237678) and in 62 patients with rare CD56-positive malignancies (NCT02452554). The gene discussed is NCAM1; the disease is acute myeloid leukemia.