Lintuzumab (SGN-33, HuM195), an unconjugated anti-CD33 mAb, has been thoroughly studied as a complement to standard induction chemotherapy and as a maintenance monotherapy in R/R AML, APL, high-risk MDS, accelerated-/blast-phase CML, and chronic myelomonocytic leukemia. This evidence concerns the gene CD33 and acute myeloid leukemia.