Furthermore, anti-CD25 mAb therapy also leads to Treg cell depletion, an effect that is exploited and studied in a clinical trial of AML, using tumor vaccination against Wilms tumor protein-1 in combination with the toll-like receptor agonist polyinosinic:polycytidylic acid and the anti-CD25 mAb basiliximab (NCT01842139). Here, IL2RA is linked to neoplasm.