BRCA1 and cancer: PC and PE lipids in cancer tissue are altered compared to normal tissue as a result of malignant progression in humans (lung cancer and breast cancer) (17, 18), in rodent models of cancer (P53 and Brca1 double-knockout), and in in vitro works (21MT-2 metastatic breast cancer cells vs 76N normal epithelial cells; hormone-resistant MB435 and MB231 breast cancer cells vs hormone-sensitive MCF-7 breast cancer cells) (42, 43).