Recently, emerging evidence illustrated that miR-21 was shuttled from cancer-associated adipocytes of fibroblasts to the various tumor cells, where it can inhibit ovarian cancer apoptosis and induce the Paclitaxel resistance through binding to its new direct target, apoptotic protease activating factor-1 (APAF1) (Yeung et al., 2016). The gene discussed is APAF1; the disease is ovarian carcinoma.