Common types of gene mutation are FGFR2 p.Ser252Trp (S252W) of 755C > G and p.Pro253Arg (P253R) of 758C > G. S252W mutation of FGFR2 is usually accompanied by severe skeletal malformations of craniofacial and higher incidence of cleft palate, but P253R mutation of FGFR2 is often accompanied by more prominent syndactyly of hands and feet (Slaney et al., 1996). Here, FGFR2 is linked to cleft palate.