On the other hand, miR-9, by direct targeting of NOTCH1, can reveal a suppressor-like activity in metastatic breast cancer cells (Mohammadi-Yeganeh et al., 2015) and also epigenetic inactivation of the miR-9 gene has been shown in human BC (Lehmann et al., 2008). This evidence concerns the gene NOTCH1 and breast carcinoma.