In cancer cells the pRB pathway is disabled by numerous mechanisms including; inactivating and/or gene mutations with in the Rb1 loci (Friend et al., 1986), the E7 oncoprotein produced by the Human Papilloma Virus (Dyson et al., 1989), the amplification or overexpression Cyclin D and/or Cyclin Dependent Kinase 4 or 6 (CDK4 and CDK6) (Nobori et al., 1994; Connell-Crowley et al., 1997; Harbour et al., 1999) or by the deletion or silencing of CDK inhibitors, CDKN2A-D (Cairns et al., 1994). The gene discussed is RB1; the disease is cancer.