Additional studies linked the Mouse double minute 2 homolog (MDM2) and Tumor Protein 53 (p53) signaling node as being dysregulated in Retinoblastoma’s (de Oliveira Reis et al., 2012; Qi and Cobrinik, 2017) and therapeutic intervention by targeting this pathway resulted in apoptosis of RB cells. Here, TP53 is linked to retinoblastoma.