Co-expression assays using NtREM-DsRed, ToMV-erGFP, and GFP/YFP-tagged virus proteins showed that the transient expression of any of the virus proteins examined (i.e., the combination of the 126K and 183K proteins, the 126K protein, and the MP) as well as the virus infection can disturb the uniform localization of NtREM-DsRed and promote the formation of NtREM-DsRed aggregates. This evidence concerns the gene PPP1CB and viral infectious disease.