CD4 and colitis: In addition, CXCR3 deficiency mediated inhibition of CD4+ T cell differentiation into Th17 cells was likely to be another driver for the alleviated colitis, although the relative mean fluorescent intensity (RMFI) of transcription factors T-bet and RORγt in both hepatic and MLN CD4+ T cells had no significant difference (Figures S3E,F in Supplementary Material).