For the opposite disease severity, we speculate the differentiation of CD8+ T cells was the main cause for aggravated cholangitis with second decreased Th17 response, while the decreased Th17 response was important for alleviated colitis after CXCR3 deficiency in CD25−/− mice (Figures 5 and 6; Figure S5D in Supplementary Material). The gene discussed is CD8A; the disease is cholangitis.