Along these lines, normalization of CD4+ T cell metabolism by mitochondrial metabolism inhibitor metformin and the glucose metabolism inhibitor 2-Deoxy-d-glucose reduced IFNγ production from CD4+ T cells in vitro and suppressed autoimmunity and nephritis in B6.Sle1.Sle2.Sle3 mice and NZB/W F1 mice (115). Here, CD4 is linked to nephritis.