CD8A and glomerulonephritis: Moesin-deficient mice, which exhibit significantly lower levels of pERM (69), develop systemic autoimmune phenotype including glomerulonephritis (70), and exhibit reduced CD8+CD44+CD122+Ly49+ regulatory T (Treg) cells and defects in the signal transducer and activator of transcription (STAT) 5 activation by IL-15, which is known to regulate the development of CD8 Treg cells.