PI3Kδ inhibition by GS-9289, a selective inhibitor of p110δ subunit, prolongs life span and reduces kidney damage in MRL/lpr mice (97), and general PI3K inhibition by Ly294002 rescues the AICD defect in T cells from SLE patients (96), suggesting that PI3K inhibitors may be potentially important drugs to treat patients with SLE. Here, PIK3CD is linked to Nephropathy.