Recent description of a HIES phenotype with craniosynostosis, and scoliosis in mutations of the IL6ST gene encoding the gp130 receptor, and of isolated craniosynostosis, maxillary hypoplasia, delayed tooth eruption, supernumerary teeth, and minor digital anomalies in IL-11RA mutations (15, 16), strongly suggests involvement of the IL-11/gp130/STAT3 axis in craniofacial and dental features. The gene discussed is IL6ST; the disease is scoliosis.