CCR5 and respiratory tract infectious disorder: The loss of CXCR3+CCR5+CCR6−CXCR6− MAIT cells (which predominated in healthy individuals) may be particularly detrimental to respiratory infections such as Mtb, as multiple studies have demonstrated a role for CCR5 and CXCR3 co-expression in trafficking of T cells to the lung during TB infection (16, 45).